Lazio suffered their worst ever home defeat as champions Inter thrashed 6-0 in Rome.
Lazio started the night level on points with Inter Milan and sit top of the Europa League table, but had no answer to a stunning attacking display from Simone Inzaghi’s side.
They are unbeaten in 12 home games and haven’t lost in front of their own fans since March.
Hakan Calhanoglu put Inter ahead from the spot in the 41st minute following a penalty for handball, and Federico Dimarco doubled the lead before the break with a volley.
Nicolo Barella made it 3-0 six minutes after the restart before Denzel Dumfries scored two minutes later and Carlos Augusto and Marcus Thuram completed the rout late on.
Inter remain third in the standings with 34 points from 15 matches and trail leaders Atalanta by three points with a game in hand.
Lazio’s previous record home defeat was a 5-0 defeat by Fiorentina in 1959.
Their three biggest defeats in Serie A have all come at Internazionale: this defeat follows 8-1 (in 1934) and 7-0 (in 1961) defeats at Milan.